December 30, 2023 A recent study by researchers from the Institute of Advanced Study in Science and Technology (IASST), an autonomous institute of the Department of Science and Technology (DST), highlights the potential of natural anti-infective, antiviral, anti-inflammatory, and antithrombotic products derived from easily sourced mushrooms to combat COVID-19.
The paper emphasizes the importance of edible mushrooms, particularly in North-East India, and their bioactive compounds in attenuating complications associated with viral infections, including COVID-19.
Led by Prof. Ashis K Mukherjee, Director of IASST, the research group, which includes Dr. Aparup Patra, Dr. M. R. Khan, Dr. Sagar R. Barge, and Mr. Paran Baruah, critically analyzed the therapeutic potential of 13 different mushroom-derived bioactive compounds. The focus was on assessing their roles and mechanisms in preventing SARS-CoV-2 infection and mitigating associated pathophysiological effects, such as lung infection, inflammation, cytokine storms, and thrombotic and cardiovascular issues.
Mushrooms are known to contain bioactive polysaccharides and compounds with immunomodulating, antiviral, antibacterial, and antifungal properties. The researchers noted that mushroom-based drugs are currently undergoing human trials, showing promising results against SARS-CoV-2. The study emphasizes that the main advantages of using edible mushrooms against viral infections include their potential as nutraceutical supplements with no side effects, serving as immunity boosters.
The review article, published in the Journal of Fungi, suggests that there are significant opportunities for further understanding the role of mushroom-derived bioactive compounds through in-depth pre-clinical and clinical studies. The researchers advocate for coordination between scientists, health professionals, and policymakers to explore and harness the full potential of mushroom-based compounds in the fight against COVID-19 and other viral infections.
Edited by: Vaishali Verma
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