It is possible that infected children, many of whom are too young to be vaccinated, may have Covid-19 infections that are mild or have no symptoms that have not been detected, the Lancet study said. A series of cases that may have been caused by an undiagnosed SARS-CoV-2 coronavirus infection may trigger the mysterious cases of severe hepatitis reported in hundreds of young children worldwide, researchers suggest.
Children with COVID-19 are at higher risk for subsequent liver dysfunction, according to a report submitted Saturday to medRxiv prior to peer review. But most children with acute hepatitis – usually rare in that age group – do not report previous SARS-CoV-2 infections. Instead, most have been diagnosed with an adenovirus called 41F, which is not known to attack the liver.
It is possible that infected children, many of whom are too young to be vaccinated, may have mild or undiagnosed COVID infections, a separate team of researchers suggests in Lancet Gastroenterology &Hepatology. If that were true, they thought that long-term coronavirus cells in the gastrointestinal tract in these children may cause the immune system to respond to adenovirus-41F with high levels of inflammatory proteins that eventually damage the liver.
We suggest that children with acute hepatitis be investigated for SARS-CoV-2 persistence in the chair “and other signs that liver damage is occurring because the coronavirus spike protein” is a superantigen “that makes the immune system extremely sensitive.
Standing down does not help alert patients
In patients who are hospitalized with COVID-19 who are breathing alone but with high oxygen content, sleeping on the floor may not help that they may eventually need mechanical ventilation, according to a new study.
In the study, 400 patients were randomly assigned to general or general care and abdominal care, a position known to improve patient morbidity in mechanized ventilators. Over the next 30 days, 34.1% of the vertebrate group and 40.5% of the general caregiver group needed to be fitted with a ventilator, a statistically significant difference. There may have been a reduction in the risk of intubation by a normal standing among some patients, the researchers said Monday at JAMA, but could not confirm the figures from their data. The average length of the normal daily stand was approximately five hours, less than the target of eight to 10 hours a day.
Long hours of alertness are challenging and strongly influenced by the patient’s comfort and preferences, “the researchers said.”
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